Basic Information
VIS ID
TVIS44007986
Fusion event
HTLV-1-chr8 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q23.1
Reference genome
GRCh37/hg19
Start
108125205/107112977 (Hg38)
End
108125205/107112977 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-12123/Upstream/2628512; hsa-mir-10400/Downstream/5530516;
Nearest TSS
ENST00000518652/Upstream/342732; ENST00000520037/Downstream/182564;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/454614, chr8-CpG: 92/Downstream/969650
Nearby gene
ANGPT1(-136505) ;
Upstream sequence
gatctcaaactcctcacctcaagtgatcctcccatctgagcctcccaaagagctgggattacaggcataagTTGCTTTCTTCTTCCAAGTAATAGGAACC
Downstream sequence
CACCTTAGAAACagtaacagaaacctacttaaatctaaagcaaatgaattgatttgtgttttagtcaattctcacactgctctaaagtaatacccgagac
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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