Basic Information
VIS ID
TVIS44007992
Fusion event
HTLV-1-ARSF integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chrX
Cytoband
p22.33
Reference genome
GRCh37/hg19
Start
2973811/3055770 (Hg38)
End
2973811/3055770 (Hg38)
Orient
-
Location type
Intronic
Target gene
ARSF
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-3690-1/Upstream/446516; hsa-let-7f-2/Downstream/3328136;
Nearest TSS
ENST00000429181/Upstream/14299; ENST00000359361/Downstream/11063;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/126300, chrX-CpG: 20/Downstream/254557
Upstream sequence
ATGAAAAGGAATCCTAGGataaatatctcatcttcatcgtccctgggttggataattctgagggtctgtcgttgaatctcagtgtttctgcacagcactc
Downstream sequence
agcttcaatagcccagtggcaagctgcttcataagtacaacctctactggcttcctgcctttccctgtctctcttcctctttccctgaccaatgctccct
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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