Basic Information
VIS ID
TVIS44008007
Fusion event
HTLV-1-ATP2B4 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q32.1
Reference genome
GRCh37/hg19
Start
203649899/203680771 (Hg38)
End
203649899/203680771 (Hg38)
Orient
-
Location type
Intronic
Target gene
ATP2B4
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-1-3p ; hsa-mir-21-5p ; hsa-mir-423-5p ; hsa-mir-32-5p ; hsa-mir-92a-3p ; hsa-mir-92b-3p ; hsa-mir-1277-5p ; hsa-mir-5011-5p ; hsa-mir-190a-3p ; hsa-mir-218-5p ; hsa-mir-6806-5p ; hsa-mir-4290 ; hsa-mir-488-5p ; hsa-mir-4747-3p ; hsa-mir-6083 ; hsa-mir-642a-5p ; hsa-mir-452-3p ; hsa-mir-7106-3p ; hsa-mir-6886-3p ; hsa-mir-938 ; hsa-mir-18a-3p ; hsa-mir-7113-3p ; hsa-mir-6734-3p ; hsa-mir-6891-3p ; hsa-mir-6072 ; hsa-mir-6752-3p
Nearest miRNA
hsa-mir-101-1/Upstream/1677535; hsa-mir-1182/Downstream/1767531;
Nearest TSS
ENST00000473358/Upstream/53984; ENST00000466407/Downstream/2038;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/51046, chr1-CpG: 57/Downstream/114669
Upstream sequence
ACACTGGATACCTTTCATCTAAGATTTCCAAGCACTATTTCTATAATTCCATTCCTTTATCACTTTCTTAGGGTGGTGCGAAAAGACAGGGCCCATTCTC
Downstream sequence
TACCCAACTAAAGGTGGAAGGAACTGAGTCCTGAGAAGGCTAAGTAACAtccctgtcttcatgaagcaaacattgtagtgggtgaagacagaAAAGGTAA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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