Basic Information
VIS ID
TVIS44008023
Fusion event
HTLV-1-TRIM34 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
p15.4
Reference genome
GRCh37/hg19
Start
5664580/5643350 (Hg38)
End
5664580/5643350 (Hg38)
Orient
-
Location type
Exonic
Target gene
TRIM34
Nearest miRNA
hsa-mir-210/Upstream/1787209; hsa-let-7a-2/Downstream/1591416;
Nearest TSS
ENST00000527297/Upstream/8512; ENST00000460454/Downstream/24361;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/1035050, chr11-CpG: 32/Downstream/591188
Upstream sequence
GGTGTCTTGGGATCCCAATATTTCTCCTCTGGGAAACATTACTGGGAAGTGGACGTGTCCAAGAAAACTGCCTGGATCCTGGGGGTATACTGTAGAACAT
Downstream sequence
ATTCCCGCCATATGAAGTATGTTGTTAGAAGATGTGCAAATCGTCAAAATCTTTACACCAAATACAGACCTCTATTTGGCTACTGGGTTATAGGGTTACA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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