Basic Information
VIS ID
TVIS44008025
Fusion event
HTLV-1-METTL15 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
p14.1
Reference genome
GRCh37/hg19
Start
28441443/28419896 (Hg38)
End
28441443/28419896 (Hg38)
Orient
+
Location type
Intronic
Target gene
METTL15
miRNAs that regulate target gene
hsa-mir-4659b-3p ; hsa-mir-4659a-3p ; hsa-mir-6875-3p ; hsa-mir-6809-3p ; hsa-mir-4753-3p ; hsa-mir-942-5p ; hsa-mir-130b-5p ; hsa-mir-141-5p ; hsa-mir-6836-3p ; hsa-mir-5001-3p ; hsa-mir-6516-3p ; hsa-mir-6829-3p ; hsa-mir-6791-3p ; hsa-mir-6778-3p ; hsa-mir-6728-3p ; hsa-mir-766-3p ; hsa-mir-4267 ; hsa-mir-3607-5p ; hsa-mir-216b-5p ; hsa-mir-29a-3p ; hsa-mir-29b-3p ; hsa-mir-29c-3p ; hsa-mir-323a-3p ; hsa-mir-4735-5p
Nearest miRNA
hsa-mir-210/Upstream/362986; hsa-let-7a-2/Downstream/57585;
Nearest TSS
ENST00000527297/Upstream/92315; ENST00000524707/Downstream/96936;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/309222, chr11-CpG: 25/Downstream/1596229
Nearby gene
MIR8068(No orient, 57585)
Upstream sequence
cagataaatttaacaaagaaattgaaataattaaaaggaatcaagcagaaattctcaaatttaaaatgcaattgacatattgaagaatgtatcaaagtct
Downstream sequence
cctaatagtagaattgatcaaacagaagagagaattagtgagcatgaagacaggctattcaaaaatacacagtcagaagagacaaggaaaaaagaataaa
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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