Basic Information
VIS ID
TVIS44008031
Fusion event
HTLV-1-DCUN1D5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
102952488/103081759 (Hg38)
End
102952488/103081759 (Hg38)
Orient
-
Location type
Intronic
Target gene
DCUN1D5
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-16-5p ; hsa-mir-149-5p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-6831-3p ; hsa-mir-6821-3p ; hsa-mir-6790-3p ; hsa-mir-548s ; hsa-mir-6734-5p ; hsa-mir-1226-5p ; hsa-mir-6834-5p ; hsa-mir-6864-3p ; hsa-mir-3672 ; hsa-mir-6721-5p ; hsa-mir-3926 ; hsa-mir-4722-5p ; hsa-mir-3616-3p ; hsa-mir-769-5p ; hsa-mir-4786-5p ; hsa-mir-3190-5p ; hsa-mir-6849-3p ; hsa-mir-4433a-3p ; hsa-mir-3614-5p ; hsa-mir-7843-5p ; hsa-mir-6879-5p ; hsa-mir-6735-5p ; hsa-mir-4632-5p ; hsa-mir-4436b-3p ; hsa-mir-299-5p ; hsa-mir-3149 ; hsa-mir-3152-3p ; hsa-mir-3658 ; hsa-mir-3910 ; hsa-mir-483-3p ; hsa-mir-539-5p
Nearest miRNA
hsa-mir-10392/Upstream/1561854; hsa-let-7a-2/Downstream/768147;
Nearest TSS
ENST00000527297/Upstream/126025; ENST00000533027/Downstream/1080;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/628728, chr11-CpG: 66/Downstream/9786
Upstream sequence
ctctaggtctcagACTATTAAAAAAATGGAAGTGGGAGGGTTGATTTTATATTCCATTCAAGAAATTATGATTTGGTTCATATGAGCAAAGGCTTTTACC
Downstream sequence
CaaaaataaatatataaaatatCCACGTGTCTACATGTTAATGTCAGTTAAAAAAGAGAATTACAAACCATTAGCACTGAAAATTCAAATTTAAAAATTT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate