Basic Information
VIS ID
TVIS44008039
Fusion event
HTLV-1-HECTD4 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q24.13
Reference genome
GRCh37/hg19
Start
112704689/112266885 (Hg38)
End
112704689/112266885 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA12E
Target gene
HECTD4
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-296-3p ; hsa-mir-149-5p
Nearest miRNA
hsa-let-7i/Upstream/103564; hsa-mir-1178/Downstream/428149;
Nearest TSS
ENST00000382841/Upstream/4749; ENST00000531326/Downstream/6908;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/81874, chr12-CpG: 17/Downstream/114350
Upstream sequence
GATACATTTCTTAAATATGCTGACTAACATACATGAAGAAGTGTAAATATTATCTGAATATGCAGTTGTTTCCTTGGGGACAAAAAAAGGACGGCTGTTC
Downstream sequence
AAAGATAATTAAAGGATAATTCTTACCTTCTGTTAAGACCAGTTTAAGTAAGTTATTGATTTCAGTTTCACCTGGGTACAAGATATTTAAACCAGAGCTG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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