Basic Information
VIS ID
TVIS44008040
Fusion event
HTLV-1-KSR2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q24.23
Reference genome
GRCh37/hg19
Start
118149495/117711690 (Hg38)
End
118149495/117711690 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA12E ; FRA12C
Target gene
KSR2
miRNAs that regulate target gene
hsa-mir-940 ; hsa-mir-7847-3p ; hsa-mir-6894-5p ; hsa-mir-765 ; hsa-mir-7154-3p ; hsa-mir-4751 ; hsa-mir-766-5p ; hsa-mir-139-5p ; hsa-mir-3922-5p ; hsa-mir-5582-5p ; hsa-mir-2113 ; hsa-mir-218-5p ; hsa-mir-7106-3p ; hsa-mir-361-3p ; hsa-mir-6793-3p ; hsa-mir-483-3p ; hsa-mir-4700-3p ; hsa-mir-642a-5p ; hsa-mir-1236-3p ; hsa-mir-4469 ; hsa-mir-6515-3p ; hsa-mir-2276-5p ; hsa-mir-5188 ; hsa-mir-1243 ; hsa-mir-3654 ; hsa-mir-6892-3p ; hsa-mir-4732-5p ; hsa-mir-6832-5p ; hsa-mir-7107-3p ; hsa-mir-6753-3p ; hsa-mir-20b-3p ; hsa-mir-3137 ; hsa-mir-6856-5p ; hsa-mir-6758-5p ; hsa-mir-6739-3p ; hsa-mir-4652-3p ; hsa-mir-4743-3p ; hsa-mir-607 ; hsa-mir-511-5p ; hsa-mir-6888-3p ; hsa-mir-6715b-3p ; hsa-mir-6830-3p ; hsa-mir-3120-5p ; hsa-mir-4732-3p ; hsa-mir-6732-3p ; hsa-mir-6715a-3p ; hsa-mir-1324
Nearest miRNA
hsa-let-7i/Upstream/1283372; hsa-mir-1178/Downstream/2001944;
Nearest TSS
ENST00000382841/Upstream/34439; ENST00000544667/Downstream/177764;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/350047, chr12-CpG: 50/Downstream/49272
Nearest cancer related gene
KSR2(OG, No orient, 0)
Upstream sequence
accattatgtgtattgctatccttcctaggaagacaggagtctgggatgCAGAAAGATCTATGGATTATACAGGCCAGAAACTCTGAGGACTTTGGCTAT
Downstream sequence
ACTTCTTGCTTTGATTTCTCATGGAAGGATCTTTCTGAAATTCTCCATGGTTCTATGTATTCAACATCACCTTAAGCTCTTGCAGAGATGCCCTTAGCTC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate