Basic Information
VIS ID
TVIS44008043
Fusion event
HTLV-1-ATP8A2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr13
Cytoband
q12.13
Reference genome
GRCh37/hg19
Start
26044335/25470197 (Hg38)
End
26044335/25470197 (Hg38)
Orient
+
Location type
Intronic
Target gene
ATP8A2
miRNAs that regulate target gene
hsa-mir-30a-5p ; hsa-mir-16-5p ; hsa-mir-675-5p ; hsa-mir-1271-5p ; hsa-mir-182-5p ; hsa-mir-196a-3p ; hsa-mir-2278 ; hsa-mir-29b-1-5p ; hsa-mir-3919 ; hsa-mir-3925-5p ; hsa-mir-4468 ; hsa-mir-5087 ; hsa-mir-6501-3p ; hsa-mir-96-5p ; hsa-mir-129-5p
Nearest miRNA
hsa-mir-2276/Upstream/1307693; hsa-mir-1267/Downstream/14193837;
Nearest TSS
ENST00000623511/Upstream/1176; ENST00000491840/Downstream/96936;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/849, chr13-CpG: 49/Downstream/541952
Upstream sequence
TATTCCACTACTGCACTAACACTTGTACAAATGACTTAGCCTGACATCTTTATTTAGAAAGGTCAGGCAGTTGGACATTATTGGGGTAGAATAATGGTGC
Downstream sequence
ATATTATATGGAGGTGGAATTTTCACTTATTAAAGGAGTGTTAGATTATGCAGCTTTATTTTGGGTTTTAAGAATGACAGTTGGGCATATTTTATACTTA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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