Basic Information
VIS ID
TVIS44008068
Fusion event
HTLV-1-UBE2I integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
p13.3
Reference genome
GRCh37/hg19
Start
1364729/1314728 (Hg38)
End
1364729/1314728 (Hg38)
Orient
+
Location type
Intronic
Target gene
UBE2I
miRNAs that regulate target gene
hsa-mir-30e-5p ; hsa-mir-200c-3p ; hsa-mir-188-5p ; hsa-mir-30c-5p ; hsa-mir-1-3p ; hsa-let-7b-5p ; hsa-mir-324-5p ; hsa-mir-214-3p ; hsa-mir-195-3p ; hsa-mir-361-3p ; hsa-mir-4426 ; hsa-mir-4647 ; hsa-mir-4662b ; hsa-mir-4707-3p ; hsa-mir-566 ; hsa-mir-652-3p ; hsa-mir-6789-3p ; hsa-mir-7108-3p
Nearest miRNA
hsa-mir-3176/Upstream/544451; hsa-mir-11401/Downstream/420257;
Nearest TSS
ENST00000527434/Upstream/179; ENST00000564143/Downstream/597;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/233, chr16-CpG: 41/Downstream/4324
Upstream sequence
CTGGGCCTGGCCGGGCACAGGGCTGAGCTGTGGCAGAGGGGAAGGGGCTCTGATGTGTGTTGGGAGCAGGCCTGAGGGGCGGGCAGCCTTTGCGTGCTGG
Downstream sequence
AACCCGGGATTCTGCTGTGTCCTTCCAGGTGTGGCTCAGGTCGCGGGAGCTGGGTTTGCAGGAGAGCCACCCCGGCCTAAAACCGTCTACTGGAGAACCT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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