Basic Information
VIS ID
TVIS44008071
Fusion event
HTLV-1-RBFOX1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
p13.3
Reference genome
GRCh37/hg19
Start
7540827/7490825 (Hg38)
End
7540827/7490825 (Hg38)
Orient
-
Location type
Intronic
Target gene
RBFOX1
miRNAs that regulate target gene
hsa-mir-30a-5p ; hsa-let-7b-5p ; hsa-mir-3157-5p ; hsa-mir-153-5p ; hsa-mir-935 ; hsa-mir-4691-3p ; hsa-mir-1305 ; hsa-mir-6809-3p ; hsa-mir-6833-3p ; hsa-mir-4768-5p ; hsa-mir-498 ; hsa-mir-4753-3p ; hsa-mir-627-3p ; hsa-mir-6832-3p ; hsa-mir-562
Nearest miRNA
hsa-mir-1225/Upstream/1858259; hsa-mir-11401/Downstream/3815615;
Nearest TSS
ENST00000527434/Upstream/68047; ENST00000570626/Downstream/19297;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/186218, chr16-CpG: 22/Downstream/27368
Upstream sequence
TCACTAAACCTCAAATTGTTCATTATCTTCTAGTCTTGGTGAAACAAGCTTTCCCATGTCTCAAAAAGACCCACCTAATAAATATAATCAAGTCCCATCT
Downstream sequence
TACCCAGAAACAGCACCTGCTGTTACTCTCTGATTCTCATTGTTTTGCTCTGACATTAGGGTGTCTTTATCAGCCTAAGGATACATAGATTCTTAGACAG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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