Basic Information
VIS ID
TVIS44008072
Fusion event
HTLV-1-ARHGAP17 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
p12.1
Reference genome
GRCh37/hg19
Start
25018081/25006760 (Hg38)
End
25018081/25006760 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA16E
Target gene
ARHGAP17
miRNAs that regulate target gene
hsa-let-7b-5p ; hsa-mir-324-3p ; hsa-mir-320a ; hsa-mir-25-3p ; hsa-mir-218-5p
Nearest miRNA
hsa-mir-1225/Upstream/803529; hsa-mir-11401/Downstream/1018477;
Nearest TSS
ENST00000527434/Upstream/29304; ENST00000571219/Downstream/8501;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/276279, chr16-CpG: 66/Downstream/7986
Upstream sequence
caactattcaaccctgccactgtagtgagtggctgtgttccagtaaactttttcacaaagcaagcggtgggctggatttaccctgcaggccaaagtctcg
Downstream sequence
tgactcACAGACTAgaagatagagggaaatgaagccaatttgaggaagaagttcatgggttcaattttatcaggccatgtcagcagagatttttcaagag
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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