Basic Information
VIS ID
TVIS44008075
Fusion event
HTLV-1-ADAMTS18 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
q23.1
Reference genome
GRCh37/hg19
Start
77466610/77432713 (Hg38)
End
77466610/77432713 (Hg38)
Orient
-
Location type
Intronic
Target gene
ADAMTS18
miRNAs that regulate target gene
hsa-mir-4680-5p ; hsa-mir-6823-5p ; hsa-mir-129-5p ; hsa-mir-6885-3p ; hsa-mir-6854-5p ; hsa-mir-599 ; hsa-mir-588 ; hsa-mir-4701-5p ; hsa-mir-3161 ; hsa-mir-4684-5p ; hsa-mir-942-5p ; hsa-mir-1251-5p ; hsa-mir-517-5p ; hsa-mir-645 ; hsa-mir-3163 ; hsa-mir-3662 ; hsa-mir-130b-5p ; hsa-mir-4753-3p ; hsa-mir-7158-5p
Nearest miRNA
hsa-mir-1225/Upstream/563694; hsa-mir-11401/Downstream/3952305;
Nearest TSS
ENST00000527434/Upstream/265; ENST00000564358/Downstream/669;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/219597, chr16-CpG: 99/Downstream/1699
Nearest cancer related gene
ADAMTS18(TSG, No orient, 0)
Upstream sequence
GGCACAGAATGGGAAACTACTTTGGAAAGTGTTTAGAAAGCTGTTGAATAATGACGAGGTATGTTTGAGTCACTTGGGTCCCCAGTTACTGGAGGAGGAA
Downstream sequence
AAGGAAGAGAAATTTCTCTTTTCCCTAAACAGTCAACAACCTTCCCCCTCCTCCAATAAAAAAAAAAAAACTAAGGAATAGTGGAGCCCCTGTAGCTAGC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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