Basic Information
VIS ID
TVIS44008099
Fusion event
HTLV-1-IGK integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
89935232/89896422 (Hg38)
End
89935232/89896422 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA2S ; FRA2L
Target gene
IGK
Nearest miRNA
hsa-mir-1285-2/Upstream/1083968; hsa-mir-10b/Downstream/6901856;
Nearest TSS
ENST00000437798/Upstream/920; ENST00000522638/Downstream/10335;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/128321, chr2-CpG: 65/Downstream/341626
Nearby gene
MIR4436A(+823264) ;
Upstream sequence
GAAAATGCACATATTTGAGTGTATATAACATACATATTAATCCATATATATTTATTTGATAACTTGTTAGCTATAAATACTATGTACACATATTCATGTG
Downstream sequence
TAGATAAGATTATTTAAatatgtttatatatatatatatatataAGCAACACATGCATACGTATGAAATTATTGTATAAATTAAATCTGTTAAGATAATT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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