Basic Information
VIS ID
TVIS44008101
Fusion event
HTLV-1-IL1R1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
102699304/102082844 (Hg38)
End
102699304/102082844 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA2S ; FRA2A
Target gene
IL1R1
miRNAs that regulate target gene
hsa-mir-197-3p ; hsa-mir-124-3p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-181d-3p
Nearest miRNA
hsa-mir-1285-2/Upstream/773310; hsa-mir-10b/Downstream/349445;
Nearest TSS
ENST00000437798/Upstream/12468; ENST00000450319/Downstream/21719;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/384478, chr2-CpG: 92/Downstream/59502
Upstream sequence
ACTGAGCTATTTGTTGCTGGGAGATGTTGTAGACTGTTGCTCGGTCAGTGCAAATGAGAGCTGCTAGCCTCGCTGTAACCTCGCTGGCTGGGTACTCTCA
Downstream sequence
GAGATTGTTAAGAGTTTTAAAATTTTTCTAATCACTAAGCATGTTAGGAAACCAGAGCTTTGTGTATGAAGAACAACTTCCTCTCAGGGACTGTACTCAA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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