Basic Information
VIS ID
TVIS44008105
Fusion event
HTLV-1-AGPS integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q31.2
Reference genome
GRCh37/hg19
Start
178346710/177481982 (Hg38)
End
178346710/177481982 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2G
Target gene
AGPS
miRNAs that regulate target gene
hsa-mir-98-5p ; hsa-mir-4709-3p ; hsa-mir-203b-3p ; hsa-mir-7158-3p ; hsa-mir-4635 ; hsa-mir-6859-5p ; hsa-mir-3916 ; hsa-mir-3125 ; hsa-mir-190a-3p ; hsa-mir-5689 ; hsa-mir-5011-5p ; hsa-mir-5580-3p ; hsa-mir-8485 ; hsa-mir-4643 ; hsa-mir-1277-5p ; hsa-mir-4789-5p ; hsa-mir-3941 ; hsa-mir-494-3p ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-5195-3p ; hsa-mir-145-5p ; hsa-mir-335-3p ; hsa-mir-3978 ; hsa-mir-6516-3p ; hsa-mir-4261 ; hsa-mir-3613-3p ; hsa-mir-1825
Nearest miRNA
hsa-mir-10b/Upstream/168100; hsa-mir-1244-1/Downstream/2378854;
Nearest TSS
ENST00000437798/Upstream/44998; ENST00000357045/Downstream/71032;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/88818, chr2-CpG: 61/Downstream/70585
Upstream sequence
AAATTTGCTTAATTTTATAATTTTTTCTAGAATGACTTGAGTAGCCATTATTCCCCAGGTAGACTTGATAAATTTAAATGTGCATAATAAATTGAATTAA
Downstream sequence
TAGATTAAATAGATTTAAATATGATTTAGAAAATTGTCATGTGATGTACTGGATTATTCCCCCTTCTTTTTTTCAGGAACTCTTGGTGTAATAACAGAAG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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