Basic Information
VIS ID
TVIS44008124
Fusion event
HTLV-1-ARMC8 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
137960095/138241253 (Hg38)
End
137960095/138241253 (Hg38)
Orient
+
Location type
Intronic
Target gene
ARMC8
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-let-7a-3p ; hsa-let-7f-5p ; hsa-let-7c-5p ; hsa-mir-19b-3p ; hsa-mir-19a-3p
Nearest miRNA
hsa-let-7g/Upstream/3803347; hsa-mir-1224/Downstream/13324623;
Nearest TSS
ENST00000440867/Upstream/3233; ENST00000464181/Downstream/22258;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/53234, chr3-CpG: 56/Downstream/88098
Upstream sequence
gtaaaattgGACTCATGGATACCACTGCTAATTCCAGCAAGTTACTGGGAAAACCTAGCAACTGTGATACATTTCAGTTGCATTATAGTAGAACTGGTGG
Downstream sequence
AATCTGAGTAATGGTAAGATCACTGCAGTTTTAAAGCTGTATTTTGTTTTGGCAACTGTAGGTATGACTCCCCAAACCAAAAAATAAACGatattactca
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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