Basic Information
VIS ID
TVIS44008131
Fusion event
HTLV-1-LCORL integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
p15.31
Reference genome
GRCh37/hg19
Start
18024754/18023131 (Hg38)
End
18024754/18023131 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA4D
Target gene
LCORL
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-21-5p ; hsa-mir-6839-3p ; hsa-mir-4507 ; hsa-mir-3940-5p ; hsa-mir-1273e
Nearest miRNA
hsa-mir-12113/Upstream/4395174; hsa-mir-12115/Downstream/2505144;
Nearest TSS
ENST00000502981/Upstream/1255; ENST00000511431/Downstream/466377;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/481, chr4-CpG: 284/Downstream/2228522
Upstream sequence
GCTAAGCTACCCAACGTTTGCTAAGAAGTACTGTGTATTTCTGGAAATTTATTCACAAGTCTGTGGGAAATATGTTTAATTCTTCTTGGAAATCTCATAA
Downstream sequence
ACTCTGAATTCAGTACCACCTTCCCTGTTTTGTGGCTTATCCTTATCCACCTTCTTTTTCTTCCTATGAGAAAGTATTTCTTTGCTCATTATGACTTCAG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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