Basic Information
VIS ID
TVIS44008133
Fusion event
HTLV-1-DTHD1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
p14
Reference genome
GRCh37/hg19
Start
36310410/36308788 (Hg38)
End
36310410/36308788 (Hg38)
Orient
+
Location type
Intronic
Target gene
DTHD1
miRNAs that regulate target gene
hsa-mir-7106-5p ; hsa-mir-6716-5p ; hsa-mir-766-5p ; hsa-mir-6124 ; hsa-mir-3663-3p ; hsa-mir-4790-3p ; hsa-mir-6754-5p ; hsa-mir-4441 ; hsa-mir-4270 ; hsa-mir-4756-5p ; hsa-mir-6783-5p ; hsa-mir-4739 ; hsa-mir-1321 ; hsa-mir-7850-5p ; hsa-mir-6505-5p ; hsa-mir-4753-3p ; hsa-mir-7111-3p ; hsa-mir-7848-3p ; hsa-mir-130b-5p ; hsa-mir-6769b-3p ; hsa-mir-4723-3p ; hsa-mir-3183 ; hsa-mir-4667-3p ; hsa-mir-369-3p
Nearest miRNA
hsa-mir-12113/Upstream/7489120; hsa-mir-1243/Downstream/117578;
Nearest TSS
ENST00000502981/Upstream/24766; ENST00000506008/Downstream/6796;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/64021, chr4-CpG: 173/Downstream/934840
Upstream sequence
GTTCCTTTATGGGAAGATTCTAAGTGACACTTTTTAGAAATAGccttcttcacagttactatctgagtccaagctaggattatctctttcctacaggagt
Downstream sequence
aaagttgccttctaagtgcttccattattggccatatgaaatcaattaccatgtggtaataagagtgatcatttaaaaacataaatcatactatattata
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate