Basic Information
VIS ID
TVIS44008134
Fusion event
HTLV-1-ATP8A1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
p13
Reference genome
GRCh37/hg19
Start
42589029/42587012 (Hg38)
End
42589029/42587012 (Hg38)
Orient
-
Location type
Intronic
Target gene
ATP8A1
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-128-3p ; hsa-mir-181a-5p ; hsa-mir-140-3p
Nearest miRNA
hsa-mir-12113/Upstream/2084893; hsa-mir-1243/Downstream/5065657;
Nearest TSS
ENST00000502981/Upstream/30777; ENST00000562054/Downstream/1605;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/188227, chr4-CpG: 116/Downstream/69249
Upstream sequence
GGTTTTCCCTCTGGCCAACCAGAAGCAGCTGTCACTGAGCAGGGCCCCTCACACAGTGGCAGTCTGGGTCCAGGCCCTCTGTGATGATCTAGTTCCAACA
Downstream sequence
CATCCCAACCCTCCCAAATGTCATTTTCATCATTCATCTAGAAACCAAAGGCATACATTTTTAAAGTCCCTCTTAAAACTTTAAAAACTTTACAGTTATT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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