Basic Information
VIS ID
TVIS44008146
Fusion event
HTLV-1-PPP2R2B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q32
Reference genome
GRCh37/hg19
Start
146132051/146752488 (Hg38)
End
146132051/146752488 (Hg38)
Orient
-
Location type
Intronic
Target gene
PPP2R2B
miRNAs that regulate target gene
hsa-mir-30e-3p ; hsa-mir-6825-5p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-765 ; hsa-mir-6804-5p ; hsa-mir-665 ; hsa-mir-4779 ; hsa-mir-4459 ; hsa-mir-548t-3p ; hsa-mir-548ap-3p ; hsa-mir-548aa
Nearest miRNA
hsa-mir-10397/Upstream/3072517; hsa-mir-103a-1/Downstream/2309825;
Nearest TSS
ENST00000502646/Upstream/152112; ENST00000503975/Downstream/126093;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/304621, chr5-CpG: 97/Downstream/125295
Upstream sequence
ttccctgaccacccctcatcctatcagtgctgctcattttatttctcagaacttaacacatatctgaaattatcttattcattttatttgactcatttat
Downstream sequence
catccggattccccactgaaatgcaagacctaagagaataagtgccatgtctgcttagtttattgcaatatctttagtacctaattcagtgcctggatct
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate