Basic Information
VIS ID
TVIS44008149
Fusion event
HTLV-1-GABRG2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q34
Reference genome
GRCh37/hg19
Start
161570584/162143578 (Hg38)
End
161570584/162143578 (Hg38)
Orient
+
Location type
Intronic
Target gene
GABRG2
miRNAs that regulate target gene
hsa-mir-7159-3p ; hsa-mir-6873-3p ; hsa-mir-627-3p ; hsa-mir-4778-3p ; hsa-mir-1236-3p ; hsa-mir-6515-3p ; hsa-mir-6817-3p ; hsa-mir-7110-3p ; hsa-mir-26a-2-3p ; hsa-mir-26a-1-3p ; hsa-mir-6731-3p ; hsa-mir-6777-3p ; hsa-mir-4639-3p ; hsa-mir-6749-3p ; hsa-mir-6792-3p ; hsa-mir-4691-5p ; hsa-mir-4469 ; hsa-mir-136-5p ; hsa-mir-4667-3p ; hsa-mir-1470 ; hsa-mir-500a-5p ; hsa-mir-374b-5p ; hsa-mir-374a-5p
Nearest miRNA
hsa-mir-10397/Upstream/1658128; hsa-mir-103a-1/Downstream/6022267;
Nearest TSS
ENST00000502646/Upstream/15212; ENST00000506186/Downstream/329769;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/595200, chr5-CpG: 26/Downstream/1293800
Upstream sequence
AACAAAGCCCAACACATGAAACTTTTTAAAACCTTAACTAAAAATAAAGCTAGTGGACGTGAACAAAATTCAACACCCTTTCATCAGCTATGTAAAACCT
Downstream sequence
AGAACCACATCCCTTGCTAACTGTCTaaagagtcagtagggtgtaatagctaggaaattgggttttggagtcccacaaatatgggtttgacatcacacat
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate