Basic Information
VIS ID
TVIS44008193
Fusion event
HTLV-1-ERP44 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q31.1
Reference genome
GRCh37/hg19
Start
102848877/100086595 (Hg38)
End
102848877/100086595 (Hg38)
Orient
-
Location type
Intronic
Target gene
ERP44
miRNAs that regulate target gene
hsa-mir-375 ; hsa-mir-30a-5p ; hsa-mir-8081 ; hsa-mir-374a-3p ; hsa-mir-627-5p ; hsa-mir-937-5p ; hsa-mir-361-5p ; hsa-mir-7157-5p ; hsa-mir-4310 ; hsa-mir-3617-3p ; hsa-mir-6838-3p ; hsa-mir-5582-3p ; hsa-mir-548f-3p ; hsa-mir-548e-3p ; hsa-mir-548az-3p ; hsa-mir-548ar-3p ; hsa-mir-548a-3p ; hsa-mir-4503 ; hsa-mir-5701 ; hsa-mir-27b-5p ; hsa-mir-590-5p ; hsa-mir-21-5p ; hsa-mir-100-3p ; hsa-mir-4795-3p ; hsa-mir-587 ; hsa-mir-584-5p ; hsa-mir-501-5p ; hsa-mir-561-3p ; hsa-mir-548t-5p ; hsa-mir-548az-5p ; hsa-mir-548n ; hsa-mir-552-5p ; hsa-mir-136-3p ; hsa-mir-519e-5p ; hsa-mir-515-5p ; hsa-mir-6740-3p ; hsa-mir-942-5p ; hsa-mir-5695 ; hsa-mir-519d-5p ; hsa-mir-548p
Nearest miRNA
hsa-let-7a-1/Upstream/1857378; hsa-mir-12126/Downstream/6514333;
Nearest TSS
ENST00000422679/Upstream/119325; ENST00000480309/Downstream/12445;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/179404, chr9-CpG: 69/Downstream/11898
Upstream sequence
ACGACTCCATTCACTTAACAACATTTCCTTCTCTACTATTACTTTACAAACAagtatctcctacatgccagacatcatacaatgtcctttacatacatta
Downstream sequence
tatctcaatctcacaatcttgcagaattattattcccacttttagaaaaactgatattcaaaaagataaagaaatttgcctactatcacaacagctaaaa
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate