Basic Information
VIS ID
TVIS44008204
Fusion event
HTLV-1-chrX integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chrX
Cytoband
q24
Reference genome
GRCh37/hg19
Start
119757224/120623369 (Hg38)
End
119757224/120623369 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-let-7f-2/Upstream/976521; hsa-mir-105-1/Downstream/747603;
Nearest TSS
ENST00000429181/Upstream/12040; ENST00000328078/Downstream/6626;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/61996, chrX-CpG: 56/Downstream/6513
Nearby gene
MCTS1(+2208) ;
Nearest cancer related gene
MCTS1(OG, +2208) ;
Upstream sequence
TTTTCTATTACAGGTATGCCCTGCTTTAAGAACACCCAATAACTGAGTTTGTTTAAATGCATTATAGAAAAATCTGGGCATTATGAATCAGATTTGATAC
Downstream sequence
ACAAGCAACCTTTTAGCTTACTCCCCTGCCAGCCCACCGCCCCAGAAAATAGCCAAGGGGTCTAAATCTATATTTTGCTCCAGATCCAATGTTTTACTTT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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