Basic Information
VIS ID
TVIS44008214
Fusion event
HTLV-1-KAZN integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p36.21
Reference genome
GRCh37/hg19
Start
14521281/14194786 (Hg38)
End
14521281/14194786 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1A
Target gene
KAZN
Nearest miRNA
hsa-mir-12136/Upstream/1615763; hsa-mir-101-1/Downstream/2664163;
Nearest TSS
ENST00000473358/Upstream/301994; ENST00000376028/Downstream/28332;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/301544, chr1-CpG: 116/Downstream/403328
Nearby gene
PRDM2(+369707) ;
Upstream sequence
TTTTAGTTTTGTGGAGCAGCATGAGAGTATTTTGGGATAGGAGGGCATGGGCCCTTGAGGGAACGTAGCCAGCCTAAATCAGAGCAGCTGAAGGGAGGGG
Downstream sequence
AGGGGGACATGAGCCACCACTTTCTAGAGGAGTGAATCTGGAGTAGTTTGTATAATTTGGGAGTCTGGCAAGGATAGAGATTTGAGATTGAGGAGCCTCA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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