Basic Information
VIS ID
TVIS44008229
Fusion event
HTLV-1-KLF12 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr13
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
74541384/73967247 (Hg38)
End
74541384/73967247 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA13E
Target gene
KLF12
miRNAs that regulate target gene
hsa-mir-101-3p ; hsa-mir-23a-3p ; hsa-mir-4652-3p ; hsa-mir-4743-3p ; hsa-mir-218-5p ; hsa-mir-4679 ; hsa-mir-4677-3p ; hsa-mir-216b-5p ; hsa-mir-1264 ; hsa-mir-6888-3p ; hsa-mir-4775 ; hsa-mir-215-3p ; hsa-mir-6773-3p ; hsa-mir-34a-5p ; hsa-mir-141-3p ; hsa-mir-137 ; hsa-mir-200a-3p ; hsa-mir-4720-3p ; hsa-mir-4804-3p
Nearest miRNA
hsa-mir-1297/Upstream/7748923; hsa-mir-1267/Downstream/3730765;
Nearest TSS
ENST00000623511/Upstream/318994; ENST00000419499/Downstream/27802;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/907015, chr13-CpG: 31/Downstream/166725
Upstream sequence
TGGGAATCTGTTTTCCTGGCCCATGAGAAAGAGTTCACAGAAGATGGAGAGTCTGAGCATCAGAGGGGTTTAACCAAGAATGATCCATTAAAATAGGTTT
Downstream sequence
GCACCAGTTACCAAAACTGAGAAAAATGAGTTTGAATCTGTGCAGAGAGGCACAGAAATGCCAAGGTGAAGGAGCCTGCCAAGGCTGGAATACACGGTCA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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