Basic Information
VIS ID
TVIS44008233
Fusion event
HTLV-1-URI1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
q12
Reference genome
GRCh37/hg19
Start
30484239/29993332 (Hg38)
End
30484239/29993332 (Hg38)
Orient
+
Location type
Intronic
Target gene
URI1
miRNAs that regulate target gene
hsa-mir-598-3p ; hsa-mir-376a-5p
Nearest miRNA
hsa-mir-10395/Upstream/9593978; hsa-let-7e/Downstream/5129368;
Nearest TSS
ENST00000633603/Upstream/10099; ENST00000574176/Downstream/10963;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/50374, chr19-CpG: 51/Downstream/229169
Nearest cancer related gene
URI1(OG, No orient, 0)
Upstream sequence
TGAGCCTGATAGGACTTGGCAACTGATTGAATGTGAAGGTTGAGGGGAAGCATTGGATGAGTGGTGACCTAGAGGCAATGTTGTTGAcataatcaagtaa
Downstream sequence
gtttgtagatcactgcacactactttccctctaccagagagtaaaatgcacataggcacgttacttagaagccctgtaatgaaaaatatccctttagtct
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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