Basic Information
VIS ID
TVIS44008238
Fusion event
HTLV-1-CACNA2D2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p21.31
Reference genome
GRCh37/hg19
Start
50494140/50456709 (Hg38)
End
50494140/50456709 (Hg38)
Orient
+
Location type
Intronic
Target gene
CACNA2D2
miRNAs that regulate target gene
hsa-mir-6774-5p ; hsa-mir-328-5p ; hsa-mir-3151-5p ; hsa-mir-6766-5p ; hsa-mir-6756-5p ; hsa-mir-486-3p ; hsa-mir-6721-5p ; hsa-mir-6739-5p ; hsa-mir-6733-5p ; hsa-mir-3153 ; hsa-mir-4668-5p ; hsa-mir-6804-5p ; hsa-mir-4459 ; hsa-mir-4779 ; hsa-mir-4484
Nearest miRNA
hsa-mir-12127/Upstream/183412; hsa-let-7g/Downstream/218371;
Nearest TSS
ENST00000440867/Upstream/89244; ENST00000424388/Downstream/46714;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/91198, chr3-CpG: 101/Downstream/46080
Upstream sequence
CAGGAACCCTGCTGCCCTCCCAGGCCTGCCCCTCACACACTCTGCCCTTTCTCACTCAGTCCTACTTCTCAGCATCTGTCTACCTGCCCTCCTTTAGTGC
Downstream sequence
CTAACTGCCTGAACTAGGAACACGGATAGTGtcctgttccaccgcctggttttacaagagaaaattcagacagggaggggaaggtcatgcatatgaggct
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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