Basic Information
VIS ID
TVIS44008249
Fusion event
HTLV-1-PALLD integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q32.3
Reference genome
GRCh37/hg19
Start
169496993/168575842 (Hg38)
End
169496993/168575842 (Hg38)
Orient
+
Location type
Intronic
Target gene
PALLD
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-124-3p ; hsa-mir-21-5p ; hsa-mir-19b-3p ; hsa-mir-196a-5p ; hsa-mir-218-5p ; hsa-mir-6869-5p ; hsa-mir-610 ; hsa-mir-4717-5p ; hsa-mir-6856-5p ; hsa-mir-6758-5p ; hsa-mir-33b-5p ; hsa-mir-33a-5p ; hsa-mir-4279 ; hsa-mir-6749-3p ; hsa-mir-1298-5p ; hsa-mir-656-5p ; hsa-mir-3667-3p ; hsa-mir-6734-3p ; hsa-mir-3162-3p ; hsa-mir-1250-3p ; hsa-mir-483-3p ; hsa-mir-4775 ; hsa-mir-4694-5p
Nearest miRNA
hsa-mir-12113/Upstream/3189505; hsa-mir-1305/Downstream/2610342;
Nearest TSS
ENST00000502981/Upstream/38056; ENST00000513245/Downstream/55773;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/95268, chr4-CpG: 32/Downstream/55723
Upstream sequence
ctttagtacatctgagctggggcttgagattctgcattctaagaagtttccaagttatgccactgctattggcctggggaccacTGTTGAAAAgttctct
Downstream sequence
cctctggctgcatgttagaatcatccaaaatcttaaaatatcttgctgcccagaccctgccacaaaattccgtttcaattaaccttcagggaagtagggg
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate