Basic Information
VIS ID
TVIS44008251
Fusion event
HTLV-1-chr6 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
p21.1
Reference genome
GRCh37/hg19
Start
40757355/40789616 (Hg38)
End
40757355/40789616 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA6H
Nearest miRNA
hsa-mir-1236/Upstream/1715235; hsa-mir-10398/Downstream/809107;
Nearest TSS
ENST00000381078/Upstream/74253; ENST00000470917/Downstream/243371;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/189775, chr6-CpG: 39/Downstream/238447
Nearby gene
LOC101929555(No orient, 89270)
Upstream sequence
gtACACCTCTGGGTGTGTGCTCATGAGCATTAATGGCACAGAAACAGAGCACAGGCACAAAGGCAGGAAGCAGATGGCCTGGGAAAAATCCAAGGGGCTT
Downstream sequence
TTGAGGGCGCTTATTATCCCAGGCAGAGCCTTGCCTGCTTCTCTGAAGGCACATAATCAATACTTCCTGAATAATGTTGAACGATGCAATCCAGTCCTTT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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