Basic Information
VIS ID
TVIS44008254
Fusion event
HTLV-1-GOLGA7 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
p11.21
Reference genome
GRCh37/hg19
Start
41360116/41502597 (Hg38)
End
41360116/41502597 (Hg38)
Orient
+
Location type
Intronic
Target gene
GOLGA7
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-124-3p ; hsa-mir-186-5p ; hsa-mir-191-5p ; hsa-mir-16-5p ; hsa-mir-922 ; hsa-mir-6868-5p ; hsa-mir-29a-3p ; hsa-mir-29b-3p ; hsa-mir-29c-3p ; hsa-mir-338-5p ; hsa-mir-5682 ; hsa-mir-6871-3p ; hsa-mir-548c-3p ; hsa-mir-3162-5p ; hsa-mir-760 ; hsa-mir-8057 ; hsa-mir-5691 ; hsa-mir-6805-3p ; hsa-mir-6822-3p ; hsa-mir-885-3p ; hsa-mir-3194-3p ; hsa-mir-5588-5p ; hsa-mir-4799-3p ; hsa-mir-4720-5p ; hsa-mir-3128 ; hsa-mir-1322 ; hsa-mir-585-5p ; hsa-mir-770-5p ; hsa-mir-4712-5p ; hsa-mir-16-1-3p ; hsa-mir-3152-5p ; hsa-mir-4774-3p ; hsa-mir-1185-2-3p ; hsa-mir-1185-1-3p ; hsa-let-7f-2-3p ; hsa-mir-6757-5p ; hsa-mir-101-3p ; hsa-mir-1277-5p ; hsa-mir-144-3p
Nearest miRNA
hsa-mir-124-1/Upstream/231454; hsa-mir-10400/Downstream/157844;
Nearest TSS
ENST00000518652/Upstream/28; ENST00000523128/Downstream/3218;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/11535, chr8-CpG: 52/Downstream/26332
Upstream sequence
AGTGTTATTTCTCTATTGTTGCTACCCATGATAATTAGGGGACAAATGGGCTCGTGGAAGGTTCCCCTTTCAGTATCTCTCTGCCTTGTTCATGAACTAG
Downstream sequence
AAAACATCCCTTCTGCCTATGTGCTGTAATCTCTAGAAGGAACACAGGAGAGAACTTGGGTATGTTCTGAAAACAGTAAGATGTGGTGTTACTTAGCCTC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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