Basic Information
VIS ID
TVIS44008267
Fusion event
HTLV-1-chr13 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr13
Cytoband
q21.33
Reference genome
GRCh37/hg19
Start
72004068/71429936 (Hg38)
End
72004068/71429936 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA13B
Nearest miRNA
hsa-mir-1297/Upstream/5211612; hsa-mir-1267/Downstream/6268076;
Nearest TSS
ENST00000623511/Upstream/414795; ENST00000618209/Downstream/436833;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/1321849, chr13-CpG: 62/Downstream/435294
Nearby gene
DACH1(-8030) ;
Nearest cancer related gene
DACH1(TSG, -8030) ;
Upstream sequence
aaatgctagaaataaatataaaCTTACTGAATCCTCTAGAAACAGATCTTCAGTGTGAATTTTTAAAATCAACTATATTTAACCTTATGTAATATGAAAC
Downstream sequence
TACATCAGTCTTACTTTCTGCTGAAGTTTCACAATTAAGACTCTTTAAAGAAATAGCTGGGTTtttgtttgtttgtttgtttgtttgtttatttatttTG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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