Basic Information
VIS ID
TVIS44008361
Fusion event
HTLV-1-SNX25 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q35.1
Reference genome
GRCh37/hg19
Start
186259967/185338813 (Hg38)
End
186259967/185338813 (Hg38)
Orient
-
Location type
Intronic
Target gene
SNX25
miRNAs that regulate target gene
hsa-mir-375 ; hsa-mir-27b-3p ; hsa-mir-27a-3p
Nearest miRNA
hsa-mir-12113/Upstream/400373;
Nearest TSS
ENST00000502981/Upstream/17968; ENST00000513433/Downstream/14245;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/128071, chr4-CpG: 118/Downstream/57176
Upstream sequence
ttcccaacatgatttgttgaaaacactgttctttccctattgaatggtctcgacacccttgttgaaaatcactttaccatatattatttctgggctatat
Downstream sequence
tcccttgttctatatgtctgtctttaagccagtaccacactgttttgattattgtagctttgtagtaagtttagaagtcaagaagtctgagtcctccaac
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate