Basic Information
VIS ID
TVIS44008406
Fusion event
HTLV-1-SPTBN2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
66492875/66725404 (Hg38)
End
66492875/66725404 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA11H
Target gene
SPTBN2
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-16-5p ; hsa-mir-330-5p ; hsa-mir-193b-3p ; hsa-mir-222-3p ; hsa-let-7b-5p ; hsa-mir-3620-5p ; hsa-mir-1587 ; hsa-mir-106a-3p ; hsa-mir-4684-3p ; hsa-mir-7847-3p ; hsa-mir-6880-5p ; hsa-mir-4741 ; hsa-mir-4675 ; hsa-mir-762 ; hsa-mir-5001-5p ; hsa-mir-4498 ; hsa-mir-4492 ; hsa-mir-6829-5p ; hsa-mir-6851-5p ; hsa-mir-4656 ; hsa-mir-3689d ; hsa-mir-6086 ; hsa-mir-377-5p ; hsa-mir-6840-3p ; hsa-mir-6134 ; hsa-mir-665 ; hsa-mir-4459 ; hsa-mir-1273e ; hsa-mir-4709-5p ; hsa-mir-4733-5p ; hsa-mir-450a-1-3p ; hsa-mir-6783-3p ; hsa-mir-1343-3p ; hsa-mir-2355-5p ; hsa-mir-8059 ; hsa-mir-4471 ; hsa-mir-1292-5p ; hsa-mir-6886-3p ; hsa-mir-938 ; hsa-mir-4645-3p ; hsa-mir-18a-3p ; hsa-mir-3189-3p ; hsa-mir-584-3p ; hsa-mir-5190 ; hsa-mir-4446-3p ; hsa-mir-4802-3p ; hsa-mir-542-3p
Nearest miRNA
hsa-mir-10392/Upstream/1076151; hsa-let-7a-2/Downstream/209030;
Nearest TSS
ENST00000527297/Upstream/4005; ENST00000534325/Downstream/3086;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/24300, chr11-CpG: 140/Downstream/2062
Nearby gene
SPTBN2(-4005) ;
Upstream sequence
AGGTCTTGGTTTCCAAGCATTCTGGCTCTGTAGCTCCCTGGCCTTTTGGACAATATGCTGTGTTCTCAGCTTGTGTCCCCTGCTGCCATCTCTAGATTCC
Downstream sequence
CACTGATTTCTATTTGCTTTTCTCCTACACATATCCAGCGCTGGTTTCTTGCCACTGAGTAGATCATTCCTCACCTATGACCAGGGTCTCCATGCTCACA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate