Basic Information
VIS ID
TVIS44008409
Fusion event
HTLV-1-LIN52 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q24.3
Reference genome
GRCh37/hg19
Start
74667441/74200738 (Hg38)
End
74667441/74200738 (Hg38)
Orient
+
Location type
Intronic
Target gene
LIN52
miRNAs that regulate target gene
hsa-let-7d-5p ; hsa-mir-202-3p ; hsa-mir-5585-3p ; hsa-mir-6744-5p ; hsa-mir-6131 ; hsa-mir-133a-5p ; hsa-mir-4299 ; hsa-mir-512-3p ; hsa-mir-1265 ; hsa-mir-2392 ; hsa-mir-323a-3p ; hsa-mir-519c-3p ; hsa-mir-519b-3p ; hsa-mir-519a-3p ; hsa-mir-583 ; hsa-mir-373-3p ; hsa-mir-302a-3p ; hsa-mir-372-3p ; hsa-mir-520e ; hsa-mir-520a-3p ; hsa-mir-302b-3p ; hsa-mir-520b ; hsa-mir-302c-3p ; hsa-mir-520c-3p ; hsa-mir-520d-3p ; hsa-mir-302d-3p ; hsa-mir-302e ; hsa-mir-138-5p ; hsa-mir-487a-3p ; hsa-mir-154-3p ; hsa-mir-676-5p ; hsa-mir-6515-3p ; hsa-mir-603 ; hsa-mir-8485 ; hsa-mir-3591-5p ; hsa-mir-4783-5p ; hsa-mir-5698 ; hsa-mir-143-5p ; hsa-mir-4430 ; hsa-mir-3652 ; hsa-mir-122-5p ; hsa-mir-504-3p ; hsa-mir-3135b ; hsa-mir-6499-3p ; hsa-mir-6741-3p ; hsa-mir-5693 ; hsa-mir-146a-5p ; hsa-mir-4251 ; hsa-mir-4303 ; hsa-mir-4329 ; hsa-mir-4524a-3p ; hsa-mir-4762-3p ; hsa-mir-6761-5p
Nearest miRNA
hsa-mir-208a/Upstream/441919; hsa-mir-1185-1/Downstream/279395;
Nearest TSS
ENST00000550708/Upstream/115233; ENST00000261980/Downstream/38734;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/115735, chr14-CpG: 29/Downstream/17000
Nearby gene
LIN52(+324) ;
Upstream sequence
ACTTATTGAAAGGAAAAAAGACTTAACACAAGATAGGAAAGATGAGTATGAGAAGTAAAACATTCTGCTGGGGTGCTACATAGAAGGTTAGGTTGTAGGG
Downstream sequence
GCTTTGATTTTAATTTAAACTTATTATCGATTGATATTTCTGTATCTCACTAAATGCGGTTGAAGAGTGTGTGTGTGTGTGTGCGCGCGCGCATGTGGCC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate