Basic Information
VIS ID
TVIS44008411
Fusion event
HTLV-1-GANC integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q15.1
Reference genome
GRCh37/hg19
Start
42639098/42346900 (Hg38)
End
42639098/42346900 (Hg38)
Orient
-
Location type
Intronic
Target gene
GANC
Nearest miRNA
hsa-mir-1233-1/Upstream/147234; hsa-mir-10393/Downstream/1446759;
Nearest TSS
ENST00000557528/Upstream/2205; ENST00000483208/Downstream/1203;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/72694, chr15-CpG: 25/Downstream/143861
Upstream sequence
GCTATCTTGAGTTTCTAAAGGGAACTTTCTTTCTACACCTGAATTACAACCACTGCCACACTACTACAGGCCCAAAGTAGTGTGAAGATTAATAGATACT
Downstream sequence
GATATTATTTTGTAAACCATCAGCAGCAATATGAACCCCATTATTTAAAAAAATAGTTTCAGATACCAACTTtcagatctagaagagaacttaacaatta
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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