Basic Information
VIS ID
TVIS44008415
Fusion event
HTLV-1-AKAP6 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q12
Reference genome
GRCh37/hg19
Start
33168744/32699538 (Hg38)
End
33168744/32699538 (Hg38)
Orient
+
Location type
Intronic
Target gene
AKAP6
miRNAs that regulate target gene
hsa-mir-1257 ; hsa-mir-4687-3p ; hsa-mir-7974 ; hsa-mir-583 ; hsa-mir-1276 ; hsa-mir-4311 ; hsa-mir-1303 ; hsa-mir-5096 ; hsa-mir-3187-3p ; hsa-mir-4435 ; hsa-mir-588 ; hsa-mir-4701-5p ; hsa-mir-548s ; hsa-mir-7641 ; hsa-mir-197-3p ; hsa-mir-411-5p ; hsa-mir-6832-5p ; hsa-mir-193b-5p ; hsa-mir-4755-3p ; hsa-mir-4695-3p ; hsa-mir-4716-5p ; hsa-mir-4781-3p ; hsa-mir-4478 ; hsa-mir-4419b ; hsa-mir-3929 ; hsa-mir-483-5p
Nearest miRNA
hsa-mir-208a/Upstream/1684796; hsa-mir-1185-1/Downstream/4252771;
Nearest TSS
ENST00000550708/Upstream/6076; ENST00000556540/Downstream/33724;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/495829, chr14-CpG: 168/Downstream/233350
Upstream sequence
GGGCTATAAAGTGGACTTTCTATTTGAACTATTTCTTGTTATTTTTATATTGTTAGAAATTTAAGATCATTTTTTGAGTTAATTTTAAACTGCAGTCTCA
Downstream sequence
AGAGCAACCTAATTCCTATTAAAAACTAACCATTCCCTTAAATGTACTTTCTTCTTTGTTTTGAGACAGTGAGTTATACTGCCAATGACTTCCCTTCCCC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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