Basic Information
VIS ID
TVIS44008422
Fusion event
HTLV-1-YAP1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
102063180/102192449 (Hg38)
End
102063180/102192449 (Hg38)
Orient
+
Location type
Intronic
Target gene
YAP1
miRNAs that regulate target gene
hsa-let-7b-5p ; hsa-mir-630 ; hsa-mir-375 ; hsa-mir-200a-3p ; hsa-mir-26b-5p ; hsa-mir-141-3p ; hsa-mir-15a-5p ; hsa-mir-16-5p ; hsa-mir-559 ; hsa-mir-548b-5p ; hsa-mir-548a-5p ; hsa-mir-548c-5p ; hsa-mir-548d-5p ; hsa-mir-1468-3p ; hsa-mir-877-5p ; hsa-mir-548j-5p ; hsa-mir-548k ; hsa-mir-548l ; hsa-mir-548h-5p ; hsa-mir-548p ; hsa-mir-548i ; hsa-mir-3121-3p ; hsa-mir-3125 ; hsa-mir-3159 ; hsa-mir-548w ; hsa-mir-3916 ; hsa-mir-548y ; hsa-mir-548o-5p ; hsa-mir-548ab ; hsa-mir-548ad-5p ; hsa-mir-548ae-5p ; hsa-mir-548ak ; hsa-mir-548am-5p ; hsa-mir-548ap-5p ; hsa-mir-548aq-5p ; hsa-mir-548ar-5p ; hsa-mir-548as-5p ; hsa-mir-548au-5p ; hsa-mir-548av-5p ; hsa-mir-548ay-5p ; hsa-mir-6859-5p ; hsa-mir-8054 ; hsa-mir-548bb-5p ; hsa-mir-506-3p ; hsa-mir-4639-5p ; hsa-mir-6844 ; hsa-mir-138-2-3p ; hsa-mir-4272 ; hsa-mir-4729 ; hsa-mir-10a-3p ; hsa-mir-509-3p ; hsa-mir-27a-3p ; hsa-mir-195-5p ; hsa-mir-424-3p ; hsa-mir-199a-3p ; hsa-mir-138-5p
Nearest miRNA
hsa-mir-10392/Upstream/672544; hsa-let-7a-2/Downstream/1657457;
Nearest TSS
ENST00000527297/Upstream/6368; ENST00000528834/Downstream/34524;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/80850, chr11-CpG: 19/Downstream/76244
Nearest cancer related gene
YAP1(TSG, No orient, 0)
Upstream sequence
TGTTTCATATGTACATTATCCTGTGAGAAAAATAGTTATGTCATTGCTCTGACCTGTCATTTTCAATCTCCTCCAAAAATCTTTCTTCAATCTGCAGTAG
Downstream sequence
AGGCTAGCATCTCTTTTCCACATGATAGTTACAACAATGTACTTGATTCAACTGAATTAAATTGGGATGTAGAAAAATTTACCTTCTCAGTtggaaatca
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate