Basic Information
VIS ID
TVIS44008438
Fusion event
HTLV-1-ASTN1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q25.2
Reference genome
GRCh37/hg19
Start
177040180/177071044 (Hg38)
End
177040180/177071044 (Hg38)
Orient
-
Location type
Intronic
Target gene
ASTN1
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-1273e ; hsa-mir-6734-5p ; hsa-mir-1226-5p ; hsa-mir-6834-5p ; hsa-mir-3915 ; hsa-mir-1200 ; hsa-mir-7162-5p ; hsa-mir-378a-5p ; hsa-mir-516b-3p ; hsa-mir-516a-3p ; hsa-mir-6804-5p ; hsa-mir-3928-3p ; hsa-mir-544b ; hsa-mir-4324
Nearest miRNA
hsa-mir-101-1/Upstream/41599; hsa-mir-1182/Downstream/1606705;
Nearest TSS
ENST00000473358/Upstream/38494; ENST00000460161/Downstream/93639;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/863369, chr1-CpG: 44/Downstream/93212
Upstream sequence
GTCATTATTACTATCACTCACATAAATCCTAAAATTGAGCAACAATCTTTGACAGAATTAAGCAAATTATACCTTTAAATAGCTTCAGCTGCTTAAACGT
Downstream sequence
CTTCATAAGTCCAGGAACTATAAGTCCAGGAATCAGCTCAGTTCCAGTTGAGAAGCCCAGGGCAAGTCGTATTTGTACATTTCTGTAAGTACTCATTAGC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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