Basic Information
VIS ID
TVIS44008446
Fusion event
HTLV-1-ENTPD7 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q24.2
Reference genome
GRCh37/hg19
Start
101429826/99670069 (Hg38)
End
101429826/99670069 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Target gene
ENTPD7
miRNAs that regulate target gene
hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-26b-5p ; hsa-mir-15a-5p ; hsa-mir-16-5p ; hsa-mir-15b-5p ; hsa-mir-195-5p ; hsa-mir-20a-5p ; hsa-mir-106b-5p ; hsa-mir-127-5p ; hsa-mir-6806-3p ; hsa-mir-3928-5p ; hsa-mir-4690-5p ; hsa-mir-3646 ; hsa-mir-100-3p ; hsa-mir-3662 ; hsa-mir-4732-5p ; hsa-mir-6771-5p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-8085 ; hsa-mir-6731-5p ; hsa-mir-6797-5p ; hsa-mir-1249-5p ; hsa-mir-4306 ; hsa-mir-4644 ; hsa-mir-185-5p ; hsa-mir-3616-3p ; hsa-mir-6133 ; hsa-mir-6130 ; hsa-mir-6129 ; hsa-mir-6127 ; hsa-mir-4510 ; hsa-mir-4419a ; hsa-mir-6754-5p ; hsa-mir-4441 ; hsa-mir-4270 ; hsa-mir-4761-3p ; hsa-mir-4739 ; hsa-mir-4756-5p ; hsa-mir-1321 ; hsa-mir-6760-5p ; hsa-mir-4779 ; hsa-mir-6510-5p ; hsa-mir-6856-5p ; hsa-mir-2278 ; hsa-mir-6758-5p ; hsa-mir-4684-5p ; hsa-mir-942-5p ; hsa-mir-93-5p ; hsa-mir-519d-3p ; hsa-mir-20b-5p ; hsa-mir-17-5p
Nearest miRNA
hsa-mir-107/Upstream/745501; hsa-mir-1307/Downstream/1304916;
Nearest TSS
ENST00000439456/Upstream/10563; ENST00000472998/Downstream/28597;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/10237, chr10-CpG: 66/Downstream/61854
Upstream sequence
tgatctcctgacctcatgatccacccgcctcggcctcccaaagtgctgggattacaggcgtgagtcactgcgcccggccGAGATGTGTGTTTTAATCAAC
Downstream sequence
TATTTTTCTGGCATGTGCCACATAAGACATGCTCCAATATTTTCTTCAGACTCAATACATATCTTATATCCATTTATTCATTTATCTGTTTACTTATTCA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate