Basic Information
VIS ID
TVIS44008461
Fusion event
HTLV-1-MTUS2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr13
Cytoband
q12.3
Reference genome
GRCh37/hg19
Start
29732882/29158745 (Hg38)
End
29732882/29158745 (Hg38)
Orient
-
Location type
Intronic
Target gene
MTUS2
miRNAs that regulate target gene
hsa-mir-146a-5p ; hsa-mir-124-3p ; hsa-mir-4761-3p
Nearest miRNA
hsa-mir-2276/Upstream/4996241; hsa-mir-1267/Downstream/10505289;
Nearest TSS
ENST00000623511/Upstream/86761; ENST00000467990/Downstream/91809;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/337984, chr13-CpG: 31/Downstream/181004
Upstream sequence
GTGCTTATCTCTCAAGAAAAGGAGACAGGTGGAATGAGAGAAAAACAAGTCCTTCTAGCTGGATGCCTCTGAGATCTGTCCCAGTGTCTTCACCCTAACC
Downstream sequence
TGCTTCATTTTTCCCTCTGGCTTTTAGCGAAGGAGTTTTGAATTATTTTAAGATGCTCAGGGAACCCACTGTTCAAGGATAGCAGCAATGAGAAGGAGCG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate