Basic Information
VIS ID
TVIS44008462
Fusion event
HTLV-1-EPSTI1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr13
Cytoband
q14.11
Reference genome
GRCh37/hg19
Start
43464253/42890117 (Hg38)
End
43464253/42890117 (Hg38)
Orient
+
Location type
Intronic
Target gene
EPSTI1
miRNAs that regulate target gene
hsa-mir-146a-5p ; hsa-mir-654-5p
Nearest miRNA
hsa-mir-2276/Upstream/1321722; hsa-mir-1267/Downstream/1306012;
Nearest TSS
ENST00000623511/Upstream/47230; ENST00000474320/Downstream/73466;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/617446, chr13-CpG: 38/Downstream/101821
Upstream sequence
tgtgctctGCCCCGTCTGTCATACAAAAAACTAAAAAATTCAGAAATGTTGGGTGTGCTGGGCCAACTGCATACCGCATTAAATACACAATTAAGTCCCC
Downstream sequence
ATATATACTTCTTTATCTTTAGGAGTGAATTGGTTACTCTCAGTTCTTTGCTTTGATTCCAATTTATGTGAATCTATAGCTTATTTGAGAGCTCATTCCT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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