Basic Information
VIS ID
TVIS44008465
Fusion event
HTLV-1-EBPL integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr13
Cytoband
q14.2
Reference genome
GRCh37/hg19
Start
50259003/49684867 (Hg38)
End
50259003/49684867 (Hg38)
Orient
-
Location type
Intronic
Target gene
EBPL
miRNAs that regulate target gene
hsa-mir-375 ; hsa-mir-132-3p ; hsa-mir-2355-5p ; hsa-mir-7106-3p ; hsa-mir-4691-3p ; hsa-mir-140-3p
Nearest miRNA
hsa-mir-2276/Upstream/5488667; hsa-mir-1267/Downstream/311548;
Nearest TSS
ENST00000623511/Upstream/56344; ENST00000615830/Downstream/6571;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/98897, chr13-CpG: 63/Downstream/6221
Upstream sequence
agaagatttaaacaaattgagacctacccagttcttagaaggcagactgtattataaagatatcatttaatctcaaactaatctataaagttaagaaaac
Downstream sequence
cacaatcaaaataccGAGTATTAGAACTTGGCAAAGTGAAATTAttttttatttttgagacaggatcttgctctgtcgcccaggctggagtgcagtggtg
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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