Basic Information
VIS ID
TVIS44008478
Fusion event
HTLV-1-ATP10A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q12
Reference genome
GRCh37/hg19
Start
25982978/25737831 (Hg38)
End
25982978/25737831 (Hg38)
Orient
-
Location type
Intronic
Target gene
ATP10A
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-1268a/Upstream/2175700; hsa-mir-10393/Downstream/110916;
Nearest TSS
ENST00000557528/Upstream/43006; ENST00000557558/Downstream/124353;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/1586, chr15-CpG: 142/Downstream/124525
Upstream sequence
acccttatttagagaggaagtctttaaagaggtaactaaattaaactgaggtcatcagggtggaccctaatcccacatgactggcggccttatacaaagg
Downstream sequence
gaaaatcaggacgcaaagacacacagaggggagatcatgcaaggacacagggagaagccaaaaaaagaggcctcaaaagaaaccatcctgctgacccctt
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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