Basic Information
VIS ID
TVIS44008503
Fusion event
HTLV-1-MIR3681HG integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p24.3
Reference genome
GRCh37/hg19
Start
12438811/12298685 (Hg38)
End
12438811/12298685 (Hg38)
Orient
+
Location type
ncRNA_intronic
Target gene
MIR3681HG
Nearest miRNA
hsa-mir-3681/Upstream/99484; hsa-mir-10b/Downstream/438682;
Nearest TSS
ENST00000437798/Upstream/192101; ENST00000412606/Downstream/15632;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/513558, chr2-CpG: 204/Downstream/417814
Upstream sequence
TGTTTTTGTTGGACCtatttttatataataattaaaaCCAGACTGTCCTTAATTTATTCATTTCCTTTTACTGAATTACAAATTAGGTCAAATAAAGGAC
Downstream sequence
TAGGCCTCTGGAGGGTTAAAAATAATACAAATCCTAGTTTTTGAGGACTCAGGGTCTATTAGAAAAAATAAGATATGTGCATAGATGAGCATAATCTAAG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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