Basic Information
VIS ID
TVIS44008523
Fusion event
HTLV-1-NCOA6 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr20
Cytoband
q11.22
Reference genome
GRCh37/hg19
Start
33303493/34715689 (Hg38)
End
33303493/34715689 (Hg38)
Orient
-
Location type
Intronic
Target gene
NCOA6
miRNAs that regulate target gene
hsa-mir-224-5p ; hsa-mir-30b-5p ; hsa-mir-33a-5p ; hsa-mir-18a-5p ; hsa-mir-760 ; hsa-mir-361-5p ; hsa-mir-10b-5p ; hsa-mir-374a-5p
Nearest miRNA
hsa-mir-103a-2/Upstream/249271; hsa-mir-1-1/Downstream/274687;
Nearest TSS
ENST00000382410/Upstream/533; ENST00000490046/Downstream/17279;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/5251, chr20-CpG: 102/Downstream/109365
Upstream sequence
GCGATGAAGCACACTGACTAGAGAAAGTGCAGGGTGGAGAGAGCCTTTGTAGCTGGGCAATTCACCCACTGTTTCCCTCACCAGTTCTCATCATAAAACG
Downstream sequence
AAGTGTAATAGACAGACTGACAATGCTTTTGGTGAGAAATCAACGAGTAATGCCATAAGCAAATGAGTAAATTCTGTTAGAATGCAAAAAAAAACCTGCC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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