Basic Information
VIS ID
TVIS44008525
Fusion event
HTLV-1-ITSN1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr21
Cytoband
q22.11
Reference genome
GRCh37/hg19
Start
35262633/33890329 (Hg38)
End
35262633/33890329 (Hg38)
Orient
+
Location type
Intronic
Target gene
ITSN1
miRNAs that regulate target gene
hsa-mir-296-3p ; hsa-mir-194-5p
Nearest miRNA
hsa-let-7c/Upstream/339601; hsa-mir-3197/Downstream/1830386;
Nearest TSS
ENST00000624081/Upstream/14969; ENST00000610236/Downstream/17083;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/246951, chr21-CpG: 36/Downstream/25170
Nearby gene
ITSN1(+1024) ;
Upstream sequence
AAGATATGCTACCATGGTAGAAAGAAAAGTATTCAATGTGTAAATGGGGTAGTGTGGGTCACCATTCCGATCTCTTTTTGTTTTCTGTCCTGTCTTTTCT
Downstream sequence
TCATTGACTTTATTTGCGTGTTAATGTTGGACATCATTGTTCATGTAGGTAGCGTATGGTATGCACAATGACAAACAATCGTTTTAGGTCCCAGGTCACC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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