Basic Information
VIS ID
TVIS44008532
Fusion event
HTLV-1-TOP2B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p24.2
Reference genome
GRCh37/hg19
Start
25645879/25604388 (Hg38)
End
25645879/25604388 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA3A
Target gene
TOP2B
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-6513-5p ; hsa-mir-3180-5p ; hsa-mir-5089-5p ; hsa-mir-6728-5p ; hsa-mir-769-3p ; hsa-mir-450b-3p ; hsa-mir-6720-5p ; hsa-mir-6512-3p ; hsa-mir-1290 ; hsa-mir-1248 ; hsa-mir-6849-3p ; hsa-mir-3614-3p
Nearest miRNA
hsa-mir-12127/Upstream/5466747; hsa-let-7g/Downstream/60485;
Nearest TSS
ENST00000440867/Upstream/146078; ENST00000460195/Downstream/11553;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/773788, chr3-CpG: 125/Downstream/59677
Upstream sequence
CTAGTAAGAGATTCATTAATCAACTCAAAGTGTTTTGTGGCCAATCTAAGGCTGTGAAAAAGAGAGAAGCTGCATGACTCACATAGAAAAAGAGGACCTC
Downstream sequence
AACTGAGCTGACCAATCCCTCCACATAAGGAGTTGAGTCATGATCAACATAGATAACAGAAGCAAGCTACTAGCAAGACAAAATTTTAATCTCCATTACA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate