Basic Information
VIS ID
TVIS44008544
Fusion event
HTLV-1-PDCD10 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q26.1
Reference genome
GRCh37/hg19
Start
167405924/167688136 (Hg38)
End
167405924/167688136 (Hg38)
Orient
+
Location type
Intronic
Target gene
PDCD10
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-30b-5p ; hsa-mir-1-3p ; hsa-mir-30a-5p ; hsa-let-7b-5p ; hsa-mir-4776-3p ; hsa-mir-1277-5p ; hsa-mir-4652-3p ; hsa-mir-5007-3p ; hsa-mir-190a-3p ; hsa-mir-4789-5p ; hsa-mir-3941 ; hsa-mir-6853-3p ; hsa-mir-1206 ; hsa-mir-26b-3p ; hsa-mir-5011-5p ; hsa-mir-4789-3p ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485 ; hsa-mir-335-3p ; hsa-mir-1305 ; hsa-mir-498 ; hsa-mir-302c-5p ; hsa-mir-2053 ; hsa-mir-4715-3p ; hsa-mir-3064-3p ; hsa-mir-5585-3p ; hsa-mir-4465 ; hsa-mir-26b-5p ; hsa-mir-26a-5p ; hsa-mir-1297 ; hsa-mir-203a-3p ; hsa-mir-153-5p ; hsa-mir-5697 ; hsa-mir-4495 ; hsa-mir-586 ; hsa-mir-5680 ; hsa-mir-5683 ; hsa-mir-33a-3p ; hsa-mir-186-5p ; hsa-mir-3133 ; hsa-mir-7844-5p ; hsa-mir-30c-5p ; hsa-mir-30d-5p ; hsa-mir-30e-5p ; hsa-mir-6740-3p ; hsa-mir-3182 ; hsa-mir-425-5p ; hsa-mir-103a-2-5p ; hsa-mir-200c-3p ; hsa-mir-181b-5p
Nearest miRNA
hsa-let-7g/Upstream/3516580; hsa-mir-1224/Downstream/863718;
Nearest TSS
ENST00000440867/Upstream/34153; ENST00000472941/Downstream/9819;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/307726, chr3-CpG: 37/Downstream/46452
Upstream sequence
AAAATTTTTCTTTGCTCTGGCTAATGTAGCTAAATTCAAGCTACCATGTTCTCTACTTTTGTTATTTGAACAAGGAACAATTTTATAATATTCTGCATTA
Downstream sequence
CATATAACTCAATTCTGTATTTAACAATGCTGTATGCTAGATACCTATTAGTTTTGATGTTTAACATAAAATATTTCCTCCTCAGAAAATATTCCTCTCC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate