Basic Information
VIS ID
TVIS44008546
Fusion event
HTLV-1-IL1RAP integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q28
Reference genome
GRCh37/hg19
Start
190325482/190607693 (Hg38)
End
190325482/190607693 (Hg38)
Orient
-
Location type
Intronic
Target gene
IL1RAP
miRNAs that regulate target gene
hsa-mir-204-5p ; hsa-mir-375 ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-1228-3p ; hsa-mir-146a-5p ; hsa-mir-146b-5p ; hsa-mir-510-3p ; hsa-mir-494-3p ; hsa-mir-4635 ; hsa-mir-548c-3p
Nearest miRNA
hsa-let-7g/Upstream/777684; hsa-mir-3137/Downstream/4526813;
Nearest TSS
ENST00000440867/Upstream/43510; ENST00000412080/Downstream/7615;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/93038, chr3-CpG: 35/Downstream/255022
Upstream sequence
AAAAGATAACAGAGAAGGCCTGCATGTGAAATGGAGGGGGTGGGGGAAGTAAGCCCTCCAGGCAGACGGAACAACGTGTGTGAACATTATAGCACCAATG
Downstream sequence
TAATTCCCCAGTCATCCTAAGGAATTGTTATGTGTTTGTTTTTTTCCTTCATGCCTGATTGTTTGTATACATTCTCACAACAACTTGGAATGATTGTACC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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